22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway. (Pink: FKBP12 ligand (HY-114872), Black: Linker (HY-163821), Blue: FBXO22 ligand (HY-163826))[1].
Molecular Weight:
1142.79
Purity:
95.72
Formula:
C60H76ClN5O13S
Target:
FKBP,PROTACs
Application Notes:
MCE Product type: Reference compound
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