EGFR-IN-119 (Compound 5l) is an inhibitor for EGFR with an IC50 of 84.3 nM. EGFR-IN-119 inhibits the cytotoxicity in lung cancer cell A549 with an IC50 of 1.34 µM. EGFR-IN-119 downregulates the expressions of EGFR, KRAS, and MAP2K genes, exhibits antioxidant activity through reduction of reactive oxygen species (ROS), and hyperpolarizes the mitochondrial membrane potential[1].
Molecular Weight:
469.52
Formula:
C25H19N5O3S
Target:
EGFR,p38 MAPK,Ras,Reactive Oxygen Species (ROS)
Application Notes:
Reference compound
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