AChE-IN-72 (Compound 13a) is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 0.59 µM. AChE-IN-72 inhibits BChE with an IC50 of 5.02 µM. AChE-IN-72 exhibits radical scavenging with IC50 of 5.88 µM. AChE-IN-72 exhibits iron-chelating property, inhibits Abeta1-42 aggregation, and inhibits NLRP3 inflammasome activation. AChE-IN-72 ameliorates memory impairment in Betaine (HY-B0710)-induced AD mouse model. AChE-IN-72 is blood-brain barrier (BBB) penetrable[1].
Molecular Weight:
419.47
Formula:
C24H25N3O4
Target:
Cholinesterase (ChE)
Application Notes:
Reference compound
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