GSK_WRN4 is an orally active WRN helicase inhibitor (pIC50=7.6). GSK_WRN4 induces DNA damage markers (p21, p-gammaH2AX, p-KAP1). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage[1].
Molecular Weight:
336.41
Purity:
98.85
CAS Number:
[2923008-66-4]
Formula:
C16H20N2O4S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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