UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC50=1.4 µM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC50=60.1 nM, Kd=61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (Kd=0.78 nM) to prevent SARS-CoV-2 from entering host cells[1].
Molecular Weight:
364.40
Purity:
99.61
CAS Number:
[1802068-51-4]
Formula:
C22H16N6
Target:
PIKfyve,SARS-CoV
Application Notes:
MCE Product type: Reference compound
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