JNK-IN-17 (Compound 9J) is a selective and potent JNK inhibitor with IC50 values of 0.039, 0.079 µM for JNK1 and JNK3. JNK-IN-17 can inhibit c-Jun phosphorylation with an IC50 of 0.082 µM in Streptozotocin (HY-13753)-infuced INS-1 pancreatic islet beta cells. JNK-IN-17 shows inhibition rate 33% on the four main P450 subtypes (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. JNK-IN-17 can be used for researches of neurological and metabolic disease, such as Parkinsons disease[1].
Molecular Weight:
501.54
CAS Number:
[1128096-58-1]
Formula:
C28H23N9O
Target:
JAK
Application Notes:
MCE Product type: Reference compound
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