Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), the E/Z mixture compound, is a cardiomyocyte proliferation promoting agent. GA-002 (single E configuration) is a LATS1 and LATS2 kinase inhibitor with IC50 values of 3.93 nM and 3.87 nM, respectively. GA-002 induces Hippo pathway-regulated gene, inhibits YAP/TAZ phosphorylation, and induces YAP nuclear translocation[1].
Molecular Weight:
341.40
Purity:
99.87
CAS Number:
[2351906-71-1]
Formula:
C19H23N3O3
Target:
YAP
Application Notes:
MCE Product type: Reference compound
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