LK-2 is an antagonist for ASIC1a with a Kd of 1.9 µM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 µM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1].
Molecular Weight:
300.25
Purity:
98.83
CAS Number:
[2649762-09-2]
Formula:
C12H17N2O5P
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound
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