KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC50 of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC50 in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway[1].
Molecular Weight:
657.11
CAS Number:
[3033690-83-1]
Formula:
C31H28ClF3N6O3S
Target:
ERK,p38 MAPK,Ras
Application Notes:
MCE Product type: Reference compound
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