PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC50 of 200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12D with a DC50 of 200 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of 20 nM. (Pink: KRAS inhibitor-30 (HY-164366))[1].
Molecular Weight:
953.08
CAS Number:
[3043670-74-9]
Formula:
C52H60F4N8O5
Target:
PROTACs,Ras
Application Notes:
MCE Product type: Reference compound
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