DFX117 is a selective, orally active inhibitor for PI3Kalpha and c-Met tyrosine kinase. DFX117 inhibits PI3K/Akt/mTOR pathway, inhibits the proliferation of NCI-H1975, NCI-H1993, and HCC827 with IC50s 0.02-0.08 µM. DFX117 arrests cell cycle at G0/G1 phase, induces apoptosis in A549 and NCI-H1975. DFX117 exhibits antitumor efficacy in mice[1].
Molecular Weight:
572.58
CAS Number:
[2125500-60-7]
Formula:
C26H26F2N6O5S
Target:
Akt,Apoptosis,mTOR,PI3K
Application Notes:
MCE Product type: Reference compound
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