Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation[1].
Molecular Weight:
437.44
Purity:
99.82
CAS Number:
[162852-62-2]
Formula:
C20H27N3O8
Target:
Apoptosis,Autophagy,Caspase,Necroptosis
Application Notes:
MCE Product type: Reference compound
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