SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].
Molecular Weight:
536.51
CAS Number:
[839707-55-0]
Formula:
C26H23F3N8O2
Target:
Akt,Apoptosis,ERK,MEK
Application Notes:
MCE Product type: Reference compound
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