QBS10072S is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 µM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 µM). QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S can be used for the research of glioblastoma and aggressive T-cell lymphoma[1][2].
Molecular Weight:
333.25
CAS Number:
[1802735-28-9]
Formula:
C15H22Cl2N2O2
Target:
DNA Alkylator/Crosslinker,DNA/RNA Synthesis,EAAT
Application Notes:
MCE Product type: Reference compound
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