CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways[1].
Molecular Weight:
343.42
CAS Number:
[1312024-59-1]
Formula:
C21H21N5
Target:
Apoptosis,EGFR,RET,VEGFR
Application Notes:
MCE Product type: Reference compound
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