HEI3090 is a P2X7R activator. HEI3090 stimulates dendritic cells expressing P2X7R to produce IL-18, which subsequently promotes Natural Killer cells and CD4 T cells within tumors to produce IFN-gamma, leading to a sustained antitumor response. HEI3090 can be used to enhance the efficacy of alphaPD-1 therapy in non-small cell lung cancer (NSCLC)[1].
Molecular Weight:
441.70
Purity:
99.04
CAS Number:
[2377167-56-9]
Formula:
C18H15Cl3N4O3
Target:
IFNAR,Interleukin Related,P2X Receptor
Application Notes:
MCE Product type: Reference compound
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