A-1155905 is a MCL-1 inhibitor (IC50=33.5 nM, Ki=0.58 nM) with anticancer activity. A-1155905 selectively binds to MCL-1 with sufficient affinity to disrupt the MCL-1-bim complex in living cells. A-1155905-induced death of MCL-1-dependent cell lines is caspase-dependent and occurs via apoptosis[1].
Molecular Weight:
802.93
CAS Number:
[2228052-37-5]
Formula:
C46H51FN6O6
Target:
Apoptosis,Bcl-2 Family,Caspase
Application Notes:
MCE Product type: Reference compound
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