AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD)[1].
Molecular Weight:
323.32
CAS Number:
[844435-10-5]
Formula:
C17H14FN5O
Target:
Aurora Kinase,JAK,Mitosis,STAT
Application Notes:
MCE Product type: Reference compound
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