DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 µM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy[1].
Molecular Weight:
444.48
CAS Number:
[1836209-98-3]
Formula:
C27H24O6
Target:
Akt,Apoptosis,ERK,STAT
Application Notes:
MCE Product type: Reference compound
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