KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2].
Molecular Weight:
226.17
Purity:
99.82
CAS Number:
[1161826-19-2]
Formula:
C7H7FN6O2
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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