NMS-P626 is an inhibitor of TRKA, TRKB, and TRKC, with IC50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research[1].
Molecular Weight:
603.68
CAS Number:
[942471-37-6]
Formula:
C28H35F2N7O4S
Target:
Trk Receptor
Application Notes:
MCE Product type: Reference compound
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