NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 µM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density[1].
Molecular Weight:
461.62
CAS Number:
[265646-94-4]
Formula:
C15H9BrClF3N6O
Target:
Chloride Channel
Application Notes:
MCE Product type: Reference compound
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