TQ05310 is an orally available inhibitor of IDH2 mutants, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutants. TQ05310 inhibits the production of 2-hydroxyglutarate (2-HG) and induces differentiation of cells expressing IDH2-R140Q and IDH2-R172K by inhibiting the enzymatic activity of mutant IDH2. TQ05310 can be used for the study of acute myeloid leukemia[1].
Molecular Weight:
473.37
CAS Number:
[2071196-10-4]
Formula:
C19H17F6N7O
Target:
Isocitrate Dehydrogenase (IDH)
Application Notes:
MCE Product type: Reference compound
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