WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/beta-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice[1].
Molecular Weight:
557.12
CAS Number:
[2490686-86-5]
Formula:
C18H13I2N3O2
Target:
Porcupine,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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