YLL545 is a type of vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. YLL545 can inhibit VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling factors (like phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC). YLL545 can suppress the proliferation, migration, invasion, and angiogenesis of HUVEC. YLL545 can induce apoptosis in breast cancer mice and inhibit tumor growth[1].
Molecular Weight:
414.34
CAS Number:
[1423126-69-5]
Formula:
C19H13F3N6O2
Target:
Apoptosis,ERK,STAT,VEGFR
Application Notes:
MCE Product type: Reference compound
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