TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 µM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma[1][2][3].
Molecular Weight:
354.51
Purity:
99.96
CAS Number:
[1678515-93-9]
Formula:
C18H30N2O3S
Target:
Apoptosis,Emopamil Binding Protein,Ferroptosis
Application Notes:
MCE Product type: Reference compound
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