DMTr-2-O-C22-rC (Ac)-3-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2-O-C22-rC (Ac)-3-CE-Phosphoramidite enables site-specific introduction of 2-O-C22 lipophilic modification at cytidine positions during oligonucleotide synthesis, which is used to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2-O-C22-rC (Ac)-3-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. Construction and mechanism study of DMTr-2-O-C22-rC (Ac)-3-CE-Phosphoramidite nucleic acid silencing molecules[1].
Molecular Weight:
1096.42
Purity:
98
CAS Number:
[2923115-93-7]
Formula:
C63H94N5O9P
Target:
DNA/RNA Synthesis,Phosphoramidites
Application Notes:
MCE Product type: Oligonucleotides
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