E197 is the inhibitor for DOCK5 that destroys the podosome belt structure of osteoclasts, thereby inhibiting the bone resorption (IC50=3.44 µM in human osteoclast). E197 inhibits the Rac in DOCK5 expressing HEK293 cell with an IC50 of 36 µM. E197 prevents the bone loss in mouse ovariectomized models[1].
Molecular Weight:
392.90
CAS Number:
[2378515-04-7]
Formula:
C19H21ClN2O3S
Target:
DOCK
Application Notes:
MCE Product type: Reference compound
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