Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells[1][2][3].
Molecular Weight:
521.64
Purity:
95.09
CAS Number:
[391611-36-2]
Formula:
C28H43NO8
Target:
SF3B1
Application Notes:
MCE Product type: Reference compound
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