FORX-428 is a selective and orally active Poly (ADP-ribose) glycohydrolase (PARG) inhibitor. FORX-428 exhibits strong and reversible binding to the catalytic domain of human PARG, and thereby inhibits PARG´s enzymatic activity. FORX-428 leads to the excessive accumulation of PAR chains and activates DNA damage and replication stress responses. FORX-428 selectively inhibits the proliferation of various cancer cell lines, including breast, ovarian, and gastric cancer[1].
Molecular Weight:
497.59
CAS Number:
[2922789-15-7]
Formula:
C20H25F2N7O2S2
Target:
Poly(ADP-ribose) Glycohydrolase (PARG)
Application Notes:
MCE Product type: Reference compound
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