SBI-810 hydrochloride is a functionally selected beta-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 hydrochloride modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT). SBI-810 hydrochloride fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12[1][2].
Molecular Weight:
483.05
Purity:
99.55
CAS Number:
[2772746-58-2]
Formula:
C27H35ClN4O2
Target:
Neurotensin Receptor
Application Notes:
MCE Product type: Reference compound
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