(S)-VU0637120 is a Y4R antagonist that effectively reduces the binding response of its endogenous ligand, pancreatic polypeptide (PP), on Y4R, with an IC50 value of 2.7 µM. (S)-VU0637120 binds to the allosteric site of Y4R, which is located in the core region of the Y4R transmembrane structure, near the binding pocket of pancreatic polypeptide (PP), with a KB value of 300-400 nM. (S)-VU0637120 holds potential for research in the field of metabolic diseases[1].
Molecular Weight:
397.47
CAS Number:
[1175940-86-9]
Formula:
C16H19N3O5S2
Target:
Neuropeptide Y Receptor
Application Notes:
MCE Product type: Reference compound
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