XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating alpha2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research[1].
Molecular Weight:
1404.66
CAS Number:
[701909-57-1]
Formula:
C58H85N17O16S4
Target:
Adrenergic Receptor,Monoamine Transporter
Application Notes:
MCE Product type: Reference compound
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