Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 µM (COX-2) and 17.4 µM (EGFR). Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research[1].
Molecular Weight:
400.42
CAS Number:
[129724-42-1]
Formula:
C22H24O7
Target:
Akt,COX,EGFR,PD-1/PD-L1,PI3K
Application Notes:
MCE Product type: Natural Products
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