Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl- and HCO3- uptake via Na/K/2Cl++- and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl-/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research[1][2].
Molecular Weight:
488.24
CAS Number:
[99453-84-6]
Formula:
C18H20Br2N2O2S
Target:
CFTR,Elastase
Application Notes:
MCE Product type: Reference compound
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