AM-112 is a beta-lactamase (beta-lactamase) inhibitor and antibacterial agent, with IC50 values ranging from 0.0002 µg/mL to 0.67 µg/mL against class A, C, and D beta-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections[1][2].
Molecular Weight:
298.34
CAS Number:
[414858-51-8]
Formula:
C14H22N2O5
Target:
Antibiotic,Bacterial,Beta-lactamase,Penicillin-binding protein (PBP)
Application Notes:
MCE Product type: Reference compound
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