OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-kappaB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807). OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis[1][2].
Molecular Weight:
437.57
CAS Number:
[103233-65-4]
Formula:
C26H35N3O3
Target:
Apoptosis,NF-kappaB,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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