SMER10 is a small-molecule enhancer that can induce autophagy. SMER10 can increase the number of EGFP-LC3 positive autophagosoms in COS-7 and HeLa cells, promoting the conversion of LC3-I to autophagosome-associated LC3-II. SMER10 can efficiently promote the degradation of autophagy substrates, including the mutant huntingtin protein (EGFP-HDQ74) associated with Huntingtons disease and the A53T alpha-synuclein protein associated with Parkinsons disease. SMER10 exerts neuroprotective effect[1].
Molecular Weight:
267.33
CAS Number:
[221238-83-1]
Formula:
C16H17N3O
Target:
Atg8/LC3,Autophagy,Huntingtin,alpha-synuclein
Application Notes:
MCE Product type: Reference compound
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