AU-1421 is a potassium ion (K) site-directed regulator that specifically acts on various cation transport ATPases. AU-1421 can distinguish between two different K-sensitive phosphorylation intermediate (E2P) states: for non-K transport type ATPases (such as the sarcoplasmic reticulum Ca-ATPase), after binding to AU-1421, it mimics the agonistic effect of K, significantly accelerating the hydrolysis (dephosphorylation) of E2P. For K transport type ATPases (such as the gastric mucosa H/K-ATPase and the renal Na/K-ATPase), after binding to AU-1421, it inhibits the hydrolysis of E2P, stabilizing the phosphorylated intermediate, thereby blocking the ion transport cycle. AU-1421 can be used to study the mechanism of the potassium ion pump[1].
Molecular Weight:
364.91
CAS Number:
[115717-83-4]
Formula:
C23H25ClN2
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
