Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 µM for PDE4[1]. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 µM for EGFR and p60c-src in HepG2 cells[2]. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a[3]. Butein is a SIRT1 activator (STAC).
Molecular Weight:
272.25
Purity:
99.64
CAS Number:
[487-52-5]
Formula:
C15H12O5
Target:
Apoptosis,Autophagy,EGFR,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Natural Products
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