C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs). C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F(ab)2 fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs)[1].
Molecular Weight:
1393.35
CAS Number:
[2639634-82-3]
Formula:
C86H177N5O7
Target:
Liposome
Application Notes:
MCE Product type: Oligonucleotides
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