SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133+/CD44+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers[1][2].
Molecular Weight:
853.95
CAS Number:
[178250-23-2]
Formula:
C45H59NO15
Target:
Apoptosis,c-Myc,Oct3/4
Application Notes:
MCE Product type: Reference compound
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