MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 µM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP)[1].
Molecular Weight:
429.37
Purity:
99.78
CAS Number:
[3058199-58-6]
Formula:
C16H14DCl2N5OS2
Target:
CaMK,ERK,Isotope-Labeled Compounds,Piezo Channel
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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