Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-kappaB activation.
Molecular Weight:
806.94
Purity:
99.70
CAS Number:
[1260251-31-7]
Formula:
C42H56F2N8O6
Target:
Apoptosis,HIV,IAP
Application Notes:
MCE Product type: Reference compound
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