SIRT6-IN-6 (compound 6d) is a potent and selective SIRT6 inhibitor with an IC50 of 4.93 µM and a Ki of ~10 µM. SIRT6-IN-6 shows selectivity against other members of the HDAC family (SIRT1-3 and HDAC1-11). SIRT6-IN-6 significantly increases the level of glucose transporter GLUT-1, thereby reducing blood glucose in a mouse model of type 2 diabetes. SIRT6-IN-6 can be used for type 2 diabetes research[1].
Molecular Weight:
236.28
Purity:
99.63
CAS Number:
[23491-48-7]
Formula:
C11H16N4O2
Target:
GLUT,Sirtuin
Application Notes:
MCE Product type: Reference compound
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