PPI-4955 is a subtype 1 (S1P1) agonist of sphingosine-1-phosphate receptor with an EC50 of 1.62 nM. PPI-4955-P (the active phosphorylated form) exhibits excellent receptor selectivity and affinity, and the IC50 values for hS1P1, hS1P3, hS1P4, and hS1P5 are 0.23, 2000, 6.5, and 184 nM respectively. PPI-4955 has significantly improved in vivo phosphorylation efficiency, which can reduce lymphocytes and improve cardiovascular risk. PPI-4955 can be used in immunomodulation research[1].
Molecular Weight:
467.48
CAS Number:
[911412-31-2]
Formula:
C26H24F3N3O2
Target:
SphK
Application Notes:
MCE Product type: Reference compound
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