BMS-767778 is an orally active and selective DPP4 inhibitor with Ki values of 0.94 nM, 4.9, 3.2 nM for DPP4, DPP8 and DPP9 respectively. BMS-767778 exhibits >3,000-fold selectivity over the related enzymes DPP8 and DPP9. BMS-767778 inhibits CYP-3A4 with IC50 of 5.2 µM. BMS-767778 significantly reduces blood glucose levels in high fat fed (HFD) ob/ob mice with safety profile. BMS-767778 can be used for diabetes mellitus research[1].
Molecular Weight:
407.29
CAS Number:
[915729-95-2]
Formula:
C19H20Cl2N4O2
Target:
Dipeptidyl Peptidase
Application Notes:
MCE Product type: Reference compound
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