Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCiota and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer[1][2].
Molecular Weight:
269.73
Purity:
98.16
CAS Number:
[75629-57-1]
Formula:
C16H12ClNO
Target:
Apoptosis,DNA/RNA Synthesis,Ras
Application Notes:
MCE Product type: Reference compound
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