AGN 196996 is a potent and selective RARalpha antagonist with Ki value of 2 nM, little binding affinity for RARbeta(Ki=1087 nM) and RARgamma(Ki=8523 nM). IC50 value: 2 nM(Ki) Target: RARalpha antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
Molecular Weight:
482.32
Purity:
99.76
CAS Number:
[958295-17-5]
Formula:
C24H20BrNO5
Target:
Autophagy,RAR/RXR
Application Notes:
MCE Product type: Reference compound1
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