VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].
Molecular Weight:
342.44
Purity:
99.70
CAS Number:
[893990-34-6]
Formula:
C16H14N4OS2
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound1
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